Ingliforib

Ingliforib
  • Ingoa:Ingliforib
  • Nama Putumōhio:CPD2802
  • Nama CAS:186392-65-4
  • Taumaha rāpoi:457.91
  • Tātai matū:C23H24ClN3O5
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    Ingoa matū:

    5-chloro-N-((2S,3R)-4-((3S,4R)-3,4-dihydroxypyrrolidin-1-yl)-3-hydroxy-4-oxo-1-phenylbutan-2-yl)- 1H-indole-2-carboxamide

    Waehere SMILES:

    O[C@H](C1)[C@@H](O)CN1C([C@H](O)[C@H](CC2=CC=CC=C2)NC(C3=CC4=C( N3)C=CC(Cl)=C4)=O)=O

    Waehere InChi:

    InChI=1S/C23H24ClN3O5/c24-15-6-7-16-14(9-15)10-18(25-16)22(31)26-17(8-13-4-2-1-3- 5-13)21(30)23(3 2)27-11-19(28)20(29)12-27/h1-7,9-10,17,19-21,25,28-30H,8,11-12H2,(H,26,31 )/t17-,19-,20+,21+/m0/s1

    Kī InChi:

    GVDRRZOORHCTAN-MJUUVYJYSA-N

    Kupumatua:

    Ingliforib; CP-296; CP-368; CP-368,296; CP296; CP 296; CP-368296; CP368296; CP 368296

    Wairewa:DMSO

    Rokiroki: 

    Whakaahuatanga:

    Ko te Ingliforib, e mohiotia ana ko CP-368296, he kaitaunaki glycogen phosphorylase hou. Kei a Ingliforib nga taonga antihyperglycemic me te cardioprotective. Ko te Ingliforib te aukati i te glycogen phosphorylase, te whaariki whakaiti tere i roto i te glycogenolysis, na reira ka aukati i te tuku o te glucose-1 phosphate mai i te ngota ngota glycogen i roto i te ate. Ka aukati ano tenei kaihoko i te glycogen phosphorylase i roto i te uaua ngakau, ka tiakina pea te ngakau mai i te whara ischemic myocardial ma te pupuri i te ihirangi glycogen me te whakapai ake i te hononga glycolytic-oxidative.

    Whainga: glycogen phosphorylase


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