Etoricoxib

Ingoa matū:

5-Chloro-6'-methyl-3-[4-(methylsulfonyl)phenyl]-2,3'-bipyridine

Waehere SMILES:

O=S(C1=CC=C(C2=CC(Cl)=CN=C2C3=CC=C(C)N=C3)C=C1)(C)=O

Waehere InChi:

InChI=1S/C18H15ClN2O2S/c1-12-3-4-14(10-20-12)18-17(9-15(19)11-21-18)13-5-7-16(8-6- 13)24(2,22)23/h3-11H,1-2H3

Kī InChi:

MNJVRJDLRVPLFE-UHFFFAOYSA-N

Kupumatua:

Etoricoxib, Arcoxia, L-791456, MK 0663, MK-0663, 202409-33-4

Wairewa:Wairewa i roto i te DMSO

Rokiroki:0 - 4°C mo te wa poto (ra ki nga wiki), -20°C ranei mo te wa roa (marama)

Whakaahuatanga:

Ko te Etoricoxib he rongoa whakangao, nonsteroidal anti-inflammatory drug (NSAID) me nga taonga antipyretic, analgesic, me nga antineoplastic pea. Ko te Etoricoxib e herea ana me te aukati i te enzyme cyclooxygenase-2 (COX-2), ka puta te aukati i te huringa o te waikawa arachidonic ki roto i nga prostaglandins. Ko te whakakore i te COX-2 ka taea te apoptosis me te aukati i te tipu o te pūtau puku me te angiogenesis.

Whāinga: COX-2