BI-2852

Ingoa matū:

(S)-5-hydroxy-3-(2-((((1-((1-methyl-1H-imidazol-4-yl)methyl)-1H-indol-6-yl)methyl)amino)methyl) -1H-indol-3-yl)isoindolin-1-one

Waehere SMILES:

OC(C=C1)=CC([C@@H](C2=C(CNCC3=CC4=C(C=CN4CC5=CN(C)C=N5)C=C3)NC6=CC=CC=C62) N7)=C1C7=O

Waehere InChi:

InChI=1S/C31H28N6O2/c1-36-16-21(33-18-36)17-37-11-10-20-7-6-19(12-28(20)37)14-32-15- 27-29(24-4-2-3-5-26(2 4)34-27)30-25-13-22(38)8-9-23(25)31(39)35-30/h2-13,16,18,30,32,34,38H,14- 15,17H2,1H3,(H,35,39)/t30-/m0/s1

Kī InChi:

JYEQLXOWWLNVDX-PMERELPUSA-N

Kupumatua:

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko te BI-2852 he aukati KRAS kaha e herea ana me te hononga nanomolar ki te pute, i tenei wa ka kiia he "kaore e taea," i waenga i te whakawhiti I me te II i runga i te RAS. He rereke nga miihini a BI-2852 mai i nga aukati KRAG12C covalent na te mea ka herea ki tetahi pute rereke kei roto i nga momo hohe me te kore hohe o KRAS. Ka aukati a BI-2852 i te GEF, GAP, me nga taunekeneke a te hunga whai hua me te KRAS, e arai ana ki te aukati i te tohu o raro me te paanga antiproliferative i roto i nga pūtau mutant KRAS.

Whāinga: KRAS