AZD-3409

Ingoa matū:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-((((2S,4S))-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido)-4-(methylthio) butanoate

Waehere SMILES:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

Waehere InChi:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30 -18-27(13-10-24(30)9-6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38) -28)45-34(42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29, 31,37-38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1

Kī InChi:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Kupumatua:

AZD3409; AZD-3409; AZD 3409

Wairewa: 

Rokiroki: 

Whakaahuatanga:

Ko te AZD-3409 he aukati whakawhitinga prenyl kaha. I whakaatuhia e te AZD-3409 te kaha ake i te lonafarnib. Ko te tikanga IC(50) mo te cytotoxicity o AZD3409 ko 510 i roto i nga pūtau MEF, 10,600 i roto i nga pūtau A549 me te 6,170 i roto i nga pūtau MCF7, ia. I roto i enei pūtau, ko te IC (50) mo te mahi FTase o AZD3409 mai i te 3.0 ki te 14.2 nM me te lonafarnib mai i te 0.26 ki te 31.3 nM. Ko te AZD3409 te aukati i te tawhitinga ki runga ake i te geranylgeranylation. Ko te aukati i te Farnesylation me te geranylgeranylation kaore e taea te hono ki te mahi antiproliferative o te tarukino. Kei te kaha te AZD3409 i roto i te mate pukupuku u-atete gefitinib.

Whainga: te aukati prenyl transferase