Resmetirom
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Nomen chemicum:
Resmetirom
SMILES Code:
N#CC1=NN(C2=CC(Cl)=C(OC(C=C3C(C)C)=NNC3=O)C(Cl)=C2)C(NC1=O)=O
InChi Code:
InChI=1S/C17H12Cl2N6O4/c1-7(2)9-5-13(22-23-15(9)26)29-14-10(18)3-8(4-11(14)19)25- 17(28)21-16(27)12(6-20)24-25/h3-5,7H,1-2H3;
InChi Key:
FDBYIYFVSAHJLY-UHFFFAOYSA-N
Keyword:
MGL-3196; MGL 3196; VIA 3196; VIA-3196; Resmetirom
Solubilitas:Solutum in DMSO, non in aqua
Repono:0 - 4 C ad terminum brevem (dies ad septimanas), vel -20 C ad terminum longum (menses)
Descriptio:
Resmetirom, etiam ut MGL-3196, potens est et valde selectiva thyroideae hormone receptor β agonist in iudiciis clinicis ad tractationem dyslipidemiae. Effectus commodi thyreoidis hormonum in lipidorum graduum imprimis ob actionem in hormone receptore β (THR-β) in hepate, dum adversa effectus, inclusus effectus cardiaci, mediantur per hormone receptoris thyroideae α (THR. -α).
Target: THR-β