LOXO-305;LY 3527727; Pirtobrutinib

Nomen chemicum:

(S) -5-amino-3-(4-((5-fluoro-2-methoxybenzamido)methyl)phenyl)-1-(1,1,1-trifluoropropan-2-yl)-1H-pyrazole-4- carboxamide

SMILES Code:

O=C(C1=C(N)N([C@@H](C)C(F)(F)F)N=C1C2=CC=C(CNC(C3=CC(F)CC=C3OC )=O)C=C2)N

InChi Code:

InChI=1S/C22H21F4N5O3/c1-11(22(24,25)26)31-19(27)17(20(28)32)18(30-31)13-5-3-12(4-6- 13)10-29-21(33)15-9-14(23)7-8-16(15)34-2/h3-9,11H,10,27H2,1-2H3(H2,28,32; )(H,29,33)/t11-/m0/s1

InChi Key:

FWZAWAUZXYCBKZ-NSHDSACASA-N

Keyword:

2101700-15-4；CAS：2101700-15-4；CAS:2101700-15-4；LOXO-305；LOXO 305；LOXO305；LY 3527727；LY-3527727；LY3527727；Pirtobrutinib

Solubilitas: 

Repono:Arida, obscura et ad 0 - 4 C ad terminum brevem (dies ad septimanas) vel -20 C ad terminum longum (menses ad annos).

Descriptio:

Pirtobrutinib (LOXO-305) est valde selectivum et non covalens inhibitor iuxta generationem BTK qui varias BTK C481 substitutiones mutationes inhibere potest.

Target: BTK