BMS-986195
Product Detail
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| Pack Size | Availability | Pretium (USD) |
| 100mg | In Stock | 300 |
| 500mg | In Stock | 850 |
| 1g | In Stock | 1200 |
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Nomen chemicum:
(S) -4-(3-(sed-2-ynamido) piperidin-1-yl) -5-fluoro-2,3-dimethyl-1H-indole-7-carboxamide
SMILES Code:
FC1=C(N2CCC[C@H](NC(C#CC)=O)C2)C3=C(NC(C)=C3C)C(C(N)=O)=C1
InChi Code:
InChI=1S/C20H23FN4O2/c1-4-6-16(26)24-13-7-5-8-25(10-13)19-15(21)9-14(20(22)27)18- 17(19)11(2)12(3)23-18/h9,13,23H,5,7-8,10H2,1-3H3,(H2,22,27)(H,24,26)/t13 -/m0/s1
InChi Key:
VJPPLCNBDLZIFG-ZDUSSCGKSA-N
Keyword:
BMS-986195, BMS 986195, BMS986195, 1912445-55-6
Solubilitas:Solutum in DMSO
Repono:0 - 4°C ad terminum brevem (dies ad septimanas), vel -20°C ad terminum longi (menses).
Descriptio:
BMS-986195 potens, covalent, irreversibilis inhibitor tyrosini kinasi Brutonis (BTK), membrum familiae Tec familiae tyrosinae non-receptoris kinases essentiales in antigen-dependente B-cell significans et munus. BMS-986195 plus quam 5000-plicarum selectivum pro BTK super omnes cognationes extra familiam Tec, et selectivity iugis ab 9- ad 1010-ovili intra familiam Tec. BMS-986195 inactivum BTK in toto humano sanguine cum celeri rate inactivationis (3.5×10-4 nM-1·min-1) et potenter inhibuit productionem antigen-dependens interleukin, CD86 expressionem et multiplicationem in cellulis B (IC50< 1 nM) sine effectu mensurarum antigen-arum in eisdem cellulis.
Target: BTK
