AZD-3409

Nomen chemicum:

(S)-isopropyl 2-(2-(4-fluorophenethyl)-5-(((((2S,4S)-4-(nicotinoylthio)pyrrolidin-2-yl)methyl)amino)benzamido) -4-(methylthio) butanoate

SMILES Code:

O=C(OC(C)C)[C@@H](NC(C1=CC(NC[C@H]2NC[C@@H](SC(C3=CN=CC=C3)=O) C2)=CC=C1CCC4=CC=C(F)C=C4)=O)CCSC

InChi Code:

InChI=1S/C34H41FN4O4S2/c1-22(2)43-33(41)31(14-16-44-3)39-32(40)30-18-27(13-10-24(30)9- 6-23-7-11-26(35)12-8-23)37-20-28-17-29(21-38 -28)45-34(42)25-5-4-15-36-19-25/h4-5,7-8,10-13,15,18-19,22,28-29,31,37 -38H,6,9,14,16-17,20-21H2,1-3H3,(H,39,40)/t28-,29-,31-/m0/s1

InChi Key:

HKGUHEGKBLYKHY-QMOZSOIISA-N

Keyword:

AZD3409; AZD-3409; AZD 3409

Solubilitas: 

Repono: 

Descriptio:

AZD-3409 potent prenyl transferase inhibitor est. AZD-3409 altiorem potentiam ostendit quam lonafarnib. Medium IC(50) cytotoxicitatis AZD3409 erat 510 in cellulis MEF, 10,600 in cellulis A549 et 6,170 in MCF7 cellulis, respective. In his cellulis, IC(50) pro FTase activo AZD3409 ab 3.0 ad 14.2 nM, lonafarnib ab 0.26 ad 31.3 nM. AZD3409 farnesylation latius quam geranylgeranylation vetat. Utraque inhibitio farnesylationi et geranylgeranylationis cum antiproliferatis activitate pharmaci connecti non potuit. AZD3409 activae in gefitinib-repugnantia pectoris carcinoma.

Target: prenyl transferase inhibitor