THZ2

Navê Kîmyayî:

N-[3-[[5-chloro-4-(1H-indol-3-yl)pyrimidin-2-yl]amino]fenyl]-3-[[(E)-4-(dimetîlamîno) lê-2- enoyl]amino]benzamîd

Koda SMILES:

O=C(NC1=CC=CC(NC2=NC=C(Cl)C(C3=CNC4=C3C=CC=C4)=N2)=C1)C5=CC=CC(NC(/C=C/CN (C)C)=O)=C5

Koda InChi:

InChI=1S/C31H28ClN7O2/c1-39(2)15-7-14-28(40)35-21-9-5-8-20(16-21)30(41)36-22-10-6- 11-23(17-22)37-31-34-19-26(32)29(38-31)25-18-33-27-13-4-3-12-24(25)27/h3- 14,16-19,33H,15H2,1-2H3,(H,35,40)(H,36,41)(H,34,37,38)/b14-7+

Bişkojka InChi:

FONRCZUZCHXWBD-VGOFMYFVSA-N

Keyword:

THZ-2, THZ 2, THZ2, 1604810-84-5

Çareserî:Di DMSO de çareser dibe

Embarkirinî:0 - 4 ° C ji bo demek kurt (roj heta hefte), an -20 ° C ji bo demek dirêj (mehan).

Terîf:

THZ2, analogek THZ1, bi potansiyela dermankirina kansera pêsîrê ya Sê-neyînî (TNBC), ew astengkerek hêzdar û bijartî ya CDK7 e ku bêîstîqrara THZ1 di vivo de derbas dike. IC50: CDK7= 13,9 nM; Xaneyên TNBC = 10 nM

Armanc: CDK