PRT-060318; PRT318; P142–76
Detail Produk
Tag produk
| Ukuran Paket | kasedhiyan | Rega (USD) |
| 500 mg | Ing Simpenan | 900 |
| 1g | Ing Simpenan | 1350 |
| Ukuran liyane | Entuk Kutipan | Entuk Kutipan |
Jeneng Kimia:
2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pirimidine-5-carboxamide
Kode SMILES:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Kode Inchi:
InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22, 23,24)/t14-,15+/m0/s1
Kunci InChi:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
tembung kunci:
PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Kelarutan:Larut ing DMSO
Panyimpenan:0 - 4°C kanggo jangka cendhak (dina nganti minggu), utawa -20°C kanggo jangka panjang (sasi)
katrangan:
PRT060318 minangka inhibitor tirosin kinase limpa sing kuat lan selektif (Syk; IC50 = 4 nM). 270 kinase. PRT060318 nyegah agregasi convulxin-induced plasma kaya platelet manungsa (IC50 = 2.5 μM) in vitro lan nyegah trombosis ing model tikus transgenik saka trombositopenia sing diakibatake heparin. Iki nyebabake apoptosis sel limfositik kronis (CLL) B lan nyegah sekresi kemokin CCL3, CCL4, lan CXCL13.3 PRT060318 uga nyegah chemotaxis sel CLL B lan pseudoemperipolesis.
Sasaran: Syk
