Bardoxolone metil

Jeneng Kimia:

(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-metil 11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,2,3,4,4a,5,6,6a,6b,7,8,8a, 9,10,12a,14,14a,14b-octadecahydropicene-4a-carboxylate

Kode SMILES:

O=C([C@]1(CC[C@@]2(C)[C@]3(C)CCC4C(C)(C)C(C(C#N)=C[C@]4 (C)C3=C5)=O)CCC(C)(C)C[C@]1([H])[C@@]2([H])C5=O)OC

Kode Inchi:

InChI=1S/C32H43NO4/c1-27(2)11-13-32(26(36)37-8)14-12-31(7)24(20(32)17-27)21(34)15- 23-29(5)16-19(18-33) 25(35)28(3,4)22(29)9-10-30(23,31)6/h15-16,20,22,24H,9-14,17H2,1-8H3/t20-,22 ?,24+,29+,30-,31-,32+/m1/s1

Kunci InChi:

WPTTVJLTNAWYAO-OROHISIGSA-N

tembung kunci:

Bardoxolone metil, RTA-402, RTA 402, RTA402, NSC-713200, TP-155C, Methyl-CDDO, MethylCDDO, Methyl CDDO, CDDO metil ester, 218600-53-4

Kelarutan:Larut ing DMSO

Panyimpenan:0 - 4°C kanggo jangka cendhak (dina nganti minggu), utawa -20°C kanggo jangka panjang (sasi)

katrangan:

CDDO oleanane triterpenoid sintetik (Item No. 81035) minangka aktivator Nrf2 sing nyegah proliferasi lan nyebabake diferensiasi lan apoptosis ing macem-macem sel kanker. C-28 metil ester saka CDDO (CDDO metil ester) mblokir sintesis seluler saka inducible nitric oxide synthase (iNOS) lan inducible COX-2 ing makrofag tikus sing diaktifake INF-γ kanthi nilai IC50 0,11 nM. Iki nyebabake apoptosis, nyebabake diferensiasi, lan nyegah respon inflamasi ing macem-macem sel tumor liwat inhibisi sinyal IκBα kinase / NF-κB. CDDO metil ester nduweni aktivitas antidiabetik sing kuat, ngurangi ekspresi sitokin proinflamasi ing tikus diabetes tipe 2 sing dipakani diet lemak dhuwur lan ing tikus Leprdb/db lan micu AMP-activated protein kinase lan aktivasi LKB1 ing otot lan ati.

Target: NF-kB