Sitagliptin

Sitagliptin
  • Aha:Sitagliptin
  • Nọmba katalọgụ:CPDA0100
  • Nọmba CAS:654671-77-9 (Sitagliptin Phosphate Monohydrate); 654671-78-0 (Sitagliptin Phosphate); 486460-32-6 (isi efu)
  • Arọ Molecular:407.31
  • Usoro kemịkalụ:C16H15F6N5O
  • Maka nyocha sayensị naanị, ọ bụghị maka ndị ọrịa.

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    Aha kemịkalụ:

    Sitagliptin (INN; nke amataburu dị ka MK-0431 ma ree ya n'okpuru aha azụmaahịa Januvia) bụ ọgwụ antihyperglycemic ọnụ (ọgwụ mgbochi ọrịa shuga) nke klaasị inhibitor dipeptidyl peptidase-4 (DPP-4).

    Koodu Ọchịchọ:

    O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O) )(O)O.[H]O[H]

    Koodu InChi:

    InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13 (7- 26)24-25-15 (27)16 (20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1, 2,3,4);1H2/t9-;/m1../s1

    Igodo InChi:

    GQPYTJVDPQTBQC-KLQYNRQASA-N

    Okwu:

    Sitagliptin, Sitagliptin phosphate, Januvia, Glactiv, ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6

    Solubility:Soluble na DMSO

    Nchekwa:0 - 4 Celsius C maka obere oge (ụbọchị ruo izu), ma ọ bụ -20 Celsius maka ogologo oge (ọnwa).

    Nkọwa:

    Sitagliptin (INN; nke amataburu dị ka MK-0431 ma ree ya n'okpuru aha azụmaahịa Januvia) bụ ọgwụ antihyperglycemic ọnụ (ọgwụ mgbochi ọrịa shuga) nke klaasị inhibitor dipeptidyl peptidase-4 (DPP-4). Emepụtara ya ma na-ere ya site na Merck & Co. A na-eji ọgwụ a na-egbochi enzyme a na-eji naanị ya ma ọ bụ yana yana ọgwụ antihyperglycemic ndị ọzọ (dịka metformin ma ọ bụ thiazolidinedione) maka ọgwụgwọ ọrịa shuga mellitus ụdị 2. Uru nke ọgwụ a bụ. Mmetụta akụkụ ya dị ala (dịka ọmụmaatụ, obere hypoglycemia, uru dị ntakịrị) na njikwa nke ụkpụrụ glucose ọbara. Exenatide (Byetta) na-arụkwa ọrụ site na mmetụta ya na usoro incretin.

    Ebumnuche: DPP-4


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