BAY598 R-isomer
Nkọwa ngwaahịa
Mkpado ngwaahịa
| Nha ngwugwu | Nnweta | Ọnụ ego (USD) |
| 50mg | dị na ngwaahịa | Nweta nkwuputa |
| 250mg | dị na ngwaahịa | Nweta nkwuputa |
| 500mg | dị na ngwaahịa | Nweta nkwuputa |
Aha kemịkalụ:
(R, E) - N- (1- (N'-cyano-N-- (3- (difluoromethoxy) phenyl)carbamimidoyl) -3- (3,4-dichlorophenyl) -4,5-dihydro-1H-pyrazol- 4-yl) - N-ethyl-2-hydroxyacetamide
Koodu Ọchịchọ:
CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3=N/C# N)C(CO)=O
Koodu InChi:
InChi=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 (28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3, (H,28,29)/t18-/m1/s1
Igodo InChi:
OTTJIRVZJJGFTK-GOSISDBHSA-N
Okwu:
BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer
Solubility:DMSO
Nchekwa:
Nkọwa:
BAY-598 R-isomer bụ R-isomer nke BAY589. Enwere ike iji BAY-598 R-isomer mee ihe ntụnye aka. BAY-598 bụ nyocha kemịkalụ nwere ike, peptide na-asọmpi maka SMYD2. BAY-598 nwere chemotype pụrụ iche gbasara nyocha kemịkalụ SMYD2 dị ugbu a LLY-507. BAY-598 na-egbochi in vitro methylation nke p53K370 na IC50 = 27 nM ma nwee ihe karịrị 100-fold selectivity na ndị ọzọ histone methyltransferases na ndị ọzọ na-abụghị epigenetic lekwasịrị anya. BAY-598 na-egbochi methylation nke p53K370 na sel nwere IC50.<1 µM. (N'ịga n'ihu na nke a, BAY-598 nwere ihe onwunwe ndị kwekọrọ na nyocha vivo.) A na-emepụtakwa ihe njikwa njikwa, BAY-369. BAY-369 na-egbochi in vitro methylation nke p53K370 na IC50>70 micromolar.
Ebumnuche:
