BAY-598

Aha kemịkalụ:

(S, E) -N-(1- (N'-cyano-N-- (3- (difluoromethoxy) phenyl)carbamimidoyl) -3- (3,4-dichlorophenyl) -4,5-dihydro-1H-pyrazol- 4-yl) - N-ethyl-2-hydroxyacetamide

Koodu Ọchịchọ:

CCN(C(CO)=O)[C@H]1CN(/C(NC2=CC=CC(OC(F)F)=C2)=N/C#N)N=C1C3=CC(Cl)= C (Cl)C=C3

Koodu InChi:

InChi=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22 (28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3, (H,28,29)/t18-/m0/s1

Igodo InChi:

OTTJIRVZJJGFTK-SFHVURJKSA-N

Okwu:

BAY-598; BAY 598; BAY598

Solubility:DMSO

Nchekwa: 

Nkọwa:

BAY-598 bụ nyocha kemịkalụ nwere ike, peptide na-asọmpi maka SMYD2. BAY-598 nwere chemotype pụrụ iche gbasara nyocha kemịkalụ SMYD2 dị ugbu a LLY-507. BAY-598 na-egbochi in vitro methylation nke p53K370 na IC50 = 27 nM ma nwee ihe karịrị 100-fold selectivity na ndị ọzọ histone methyltransferases na ndị ọzọ na-abụghị epigenetic lekwasịrị anya. BAY-598 na-egbochi methylation nke p53K370 na sel nwere IC50.<1 µM. (N'ịga n'ihu na nke a, BAY-598 nwere ihe onwunwe ndị kwekọrọ na nyocha vivo.) A na-emepụtakwa ihe njikwa njikwa, BAY-369. BAY-369 na-egbochi in vitro methylation nke p53K370 na IC50>70 micromolar.

Ebumnuche: nyocha kemịkalụ maka SMYD2