BAY-850

Aha kemịkalụ:

N-((R) -1-(((1s, 4S)-4-aminocyclohexyl) amino) -3- (4-cyanophenyl) propan-2-yl) -2-chloro-4-methoxy-5- (5). (((R) -1- (p-tolyl) ethyl) amino) methyl)furan-2-yl) benzamide

Koodu Ọchịchọ:

ClC(C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 =CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Koodu InChi:

InChi=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(35) 39)20-37 (34)46-3)38 (45)44-31 (18-26-6-8-27 (21-40)9-7-26)22-43-30-14-12- 29 (41) 13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

Igodo InChi:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Okwu:

BAY-850; BAY850; BAY 850

Solubility:DMSO

Nchekwa: 

Nkọwa:

"BAY-850 bụ nyocha kemịkalụ maka ATAD2A bromodomain nke na-ewepụ acetylated H4 peptide site na ATAD2 bromodomain nwere uru IC50 nke 20 nM (HTRF). MST na BROMOscan nha na-egosi Kd nke 84.9 nM na 120 nM, n'otu n'otu. 850 na-egosiputa nhọrọ dị oke mma karịa bromodomains ndị ọzọ (ọ nweghị hits na BROMOscan na 10 µM) wee wepụ ATAD2 zuru oke na chromatin n'ime sel dị ndụ na ntinye nke 1 µM dị ka FRAP siri kpebie A naghị atụ aro 5µM (http://www.thesgc.org/chemical-probes/BAY-850)"

Ebumnuche: nyocha kemịkalụ maka ATAD2A bromodomain