SB-204990

Non Chimik:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic asid

Kòd SMILES:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Kòd InChi:

InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21) 22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

InChi kle:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Mot:

SB-204990, SB 204990, SB204990

Solibilite: 

Depo: 

Deskripsyon:

SB-204990 se prodrog ki pisan inibitè ATP sitrat-lyase SB-201076. SB-204990, lè yo te administre oralman nan rat, te absòbe nan sikilasyon sistemik la, konsantrasyon famasi ki enpòtan nan SB-201076 yo te refè nan fwa a. SB-204990 (25 mg/kg pa jou) tou diminye nivo kolestewòl plasma (jiska 23%) ak nivo trigliserid (jiska 38%) nan chen an, preferansyèlman diminye lipoprotein ki ba-dansite konpare ak kolestewòl lipoprotein ki wo. nivo. SB-204990 se yon anzim enpòtan nan kontwole rezèv substra pou sentèz lipid de novo ak yon sib potansyèl anzim pou entèvansyon ipolipidemi.

Sib: