| CHAT # | Non pwodwi | Deskripsyon |
| CPD3611 | SB-204990 | SB-204990 se prodrog ki pisan inibitè ATP sitrat-lyase SB-201076. SB-204990, lè yo te administre oralman nan rat, te absòbe nan sikilasyon sistemik la, konsantrasyon famasi ki enpòtan nan SB-201076 yo te refè nan fwa a. SB-204990 (25 mg/kg pa jou) tou diminye nivo kolestewòl plasma (jiska 23%) ak nivo trigliserid (jiska 38%) nan chen an, preferansyèlman diminye lipoprotein ki ba-dansite konpare ak kolestewòl lipoprotein ki wo. nivo. SB-204990 se yon anzim enpòtan nan kontwole rezèv substra pou sentèz lipid de novo ak yon sib potansyèl anzim pou entèvansyon ipolipidemi. |
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