kizartinib; AC-010220; AC-220

Non Chimik:

N-(5-tèt-Butilisoxazol-3-yl)-N'-{4-[7-(2-morfolin-4-iletoksi)imidazo[2,1-b][1,3]benzothiazol-2-yl ]fenil}ure

Kòd SMILES:

O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6

Kòd InChi:

InChI=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21(16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4- 9,16-18H,10-15H2,1-3H3,(H2,30,32,33,36)

InChi kle:

CVWXJKQAOSCOAB-UHFFFAOYSA-N

Mot:

Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)

Deskripsyon:

Quizartinib se yon inibitè nan FMS ki gen rapò ak tirozin kinaz 3 (FLT3; Kd = 1.6 nM) epi li demontre segondè selektivite pou FLT3 lè yo teste kont yon panèl 227 kinaz adisyonèl. Li inibit pwopagasyon liy selil lesemi imen MV4-11, ki gen yon mitasyon omozigòt FLT3-ITD, ak yon valè IC50 0.56 nM.1 Nan 1 mg/kg/jou, yo montre kizartinib pwolonje siviv nan yon sourit. modèl FLT3-ITD egi myeloid lesemi ak elimine timè nan yon modèl ksenograft sourit FLT3-depandan nan 10 mg / kg.

Sib: FLT3