PRT-060318; PRT318; P142–76

Non Chimik:

2-(((1R,2S)-2-aminocyclohexyl)amino)-4-(m-tolylamino)pirimidin-5-carboxamide

Kòd SMILES:

O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N

Kòd InChi:

InChI=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7-14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22, 23,24)/t14-,15+/m0/s1

InChi kle:

NZNTWOVDIXCHHS-LSDHHAIUSA-N

Mot:

PRT-060318,PRT318, P142–76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7

Solibilite:Soluble nan DMSO

Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa)

Deskripsyon:

PRT060318 se yon inibitè ki pisan ak selektif nan larat tirozin kinaz (Syk; IC50 = 4 nM). Li se selektif, anpeche 92% nan aktivite Syk, pandan y ap lòt kinaz kenbe> 70% aktivite, nan yon konsantrasyon nan 50 nM nan yon panèl nan. 270 kinaz. PRT060318 inibit agrégation konvulxin-pwovoke nan plasma moun rich plakèt (IC50 = 2.5 μM) nan vitro ak anpeche tronbozi nan yon modèl sourit transjenik nan tronbositopeni eparin-induit. Li pwovoke lesemi lenfositik kwonik (CLL) B selil apoptoz ak inibit sekresyon nan chemokines CCL3, CCL4, ak CXCL13.3 PRT060318 tou inibit CLL B selil chemotaxis ak pseudoempipolesis.

Sib: Syk