EED226
Pwodwi detay
Tags pwodwi
| Gwosè pake | Disponibilite | Pri (USD) |
| 25 mg | Nan stock | 300 |
| 50 mg | Nan stock | 500 |
| 100 mg | Nan stock | 800 |
Non Chimik:
N-(furan-2-ylmethyl)-8-(4-(methylsulfonyl)phenyl)-[1,2,4]triazolo[4,3-c]pirimidin-5-amine
Kòd SMILES:
O=S(C1=CC=C(C2=CN=C(NCC3=CC=CO3)N4C2=NN=C4)C=C1)(C)=O
Kòd InChi:
InChI=1S/C17H15N5O3S/c1-26(23,24)14-6-4-12(5-7-14)15-10-19-17(22-11-20-21-16(15)22) 18-9-13-3-2-8-25-13/h2-8,10-11H,9H2,1H3,(H,18,19)
InChi kle:
DYIRSNMPIZZNBK-UHFFFAOYSA-N
Mot:
EED226, EED-226, EED 226, 2083627-02-3
Solibilite:Soluble nan DMSO
Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).
Deskripsyon:
EED226 se yon inibitè trè pisan, efikas ak selektif nan EZH2 ak EZH1 evalye kont yon pakèt objektif epigenetik ak ki pa epigenetik. Li pisan diminye mak mondyal H3K27Me3 nan selil yo epi li demontre efè oaza selil yo touye nan selil ki pote yon mitasyon eterozigòt Y641N. EED226 gen pèmeyabilite modere jan yo mezire nan selil Caco-2 nan A → B = 3.0x10-6 cm / s, ak yon rapò eflu nan 7.6 [1].
Sib: EED226
