BAY-850

Non chimik:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -((((R)-1-(p-tolyl)etil)amino)methyl)furan-2-yl)benzamid

Kòd SMILES:

ClC(C(C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Kòd InChi:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(35) 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

InChi kle:

BSISGUIVBKDTQO-QIKYYPRYSA-N

Mot:

BAY-850; BAY850; BAY 850

Solibilite:DMSO

Depo: 

Deskripsyon:

"BAY-850 se yon pwofonde chimik pou bromodomain ATAD2A ki deplase peptide H4 acetylated soti nan bromodomain ATAD2 ak yon valè IC50 20 nM (HTRF). Mezi MST ak BROMOscan endike yon Kd 84.9 nM ak 120 nM-, respektivman. 850 montre selektivite ekskiz sou tout lòt bromodomains (pa gen okenn frape nan BROMOscan nan 10 µM) epi li deplase ATAD2 tout longè soti nan chromatin nan selil vivan nan yon konsantrasyon nan 1 µM jan FRAP detèmine pou evite potansyèl konsantrasyon sib ki pa espesifik nan ≥ Yo pa rekòmande 5 µM (http://www.thesgc.org/chemical-probes/BAY-850).

Sib: pwofonde chimik pou bromodomain ATAD2A