AZD-5069
Pwodwi detay
Tags pwodwi
| Gwosè pake | Disponibilite | Pri (USD) |
| 100 mg | Nan Stock | 500 |
| 500 mg | Nan Stock | 800 |
| 1g | Nan Stock | 1200 |
| Plis gwosè | Jwenn Quotes | Jwenn Quotes |
Non Chimik:
N-(2-((2,3-difluorobenzyl)thio)-6-(((2R,3S)-3,4-dihydroxybutan-2-yl)oxy)pirimidin-4-yl)azetidine-1-sulfonamide
Kòd SMILES:
O=S(N1CCC1)(NC2=NC(SCC3=CC=CC(F)=C3F)=NC(O[C@H](C)[C@@H](O)CO)=C2)=O
Kòd InChi:
InChI=1S/C18H22F2N4O5S2/c1-11(14(26)9-25)29-16-8-15(23-31(27,28)24-6-3-7-24)21-18(22- 16)30-10-12-4-2-5-13(19)17(12)20/h2,4-5,8,11,14,25-26H,3,6-7,9-10H2, 1H3,(H,21,22,23)/t11-,14+/m1/s1
InChi kle:
QZECRCLSIGFCIO-RISCZKNCSA-N
Mot:
AZD-5069, AZD5069, AZD 5069, 878385-84-3
Solibilite:Soluble nan DMSO
Depo:0 - 4 ° C pou kout tèm (jou a semèn), oswa -20 ° C pou tèm long (mwa).
Deskripsyon:
AZD-5069 se yon antagonist CXCR2 ki pisan ak selektif ak potansyèl pou anpeche migrasyon netrofil nan pasaj yo nan pasyan ki gen COPD. AZD-5069 te montre pou anpeche Liaison CXCL8 radiomarqué pou moun CXCR2 ak yon valè pIC50 de 9.1. Anplis de sa, AZD5069 inibit chemotaxis netrofil, ak yon pA2 nan apeprè 9.6, ak ekspresyon molekil adezyon, ak yon pA2 nan 6.9, an repons a CXCL1. AZD5069 se te yon antagonist tou dousman revèsib nan CXCR2 ak efè tan ak tanperati evidan sou farmakoloji a ak sinetik obligatwa. AZD-5069 se tou potansyèl itil pou pasyan nan kondisyon enflamatwa.
Sib: CXCR2