ʻO Sitagliptin
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Huahana Huahana
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Inoa Kimia:
ʻO Sitagliptin (INN; i ʻike mua ʻia ʻo MK-0431 a kūʻai ʻia ma lalo o ka inoa kalepa ʻo Januvia) he lāʻau antihyperglycemic waha (anti-diabetic lāʻau) o ka papa dipeptidyl peptidase-4 (DPP-4).
SMILES Code:
O=C(N1CC2=NN=C(C(F)(F)F)N2CC1)C[C@H](N)CC3=CC(F)=C(F)C=C3F.O=P(O )(O)O.[H]O[H]
Code InChi:
InChI=1S/C16H15F6N5O.H3O4P.H2O/c17-10-6-12(19)11(18)4-8(10)3-9(23)5-14(28)26-1-2-27- 13(7- 26)24-25-15(27)16(20,21)22;1-5(2,3)4;/h4,6,9H,1-3,5,7,23H2;(H3,1, 2,3,4);1H2/t9-;;/m1../s1
Ki InChi:
GQPYTJVDPQTBQC-KLQYNRQASA-N
huaʻōlelo:
Sitagliptin,Sitagliptin phosphate, Januvia, Glactiv, ONO-5435, MK-0431, L-000224715, 654671-77-9,654671-78-0, 486460-32-6
Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO
Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).
wehewehe:
ʻO Sitagliptin (INN; i ʻike mua ʻia ʻo MK-0431 a kūʻai ʻia ma lalo o ka inoa kalepa ʻo Januvia) he lāʻau antihyperglycemic waha (anti-diabetic drug) o ka papa dipeptidyl peptidase-4 (DPP-4) inhibitor. Ua hoʻomohala ʻia a kūʻai ʻia e Merck & Co. Hoʻohana ʻia kēia lāʻau lapaʻau enzyme-inhibiting i hoʻokahi a i hui pū ʻia me nā lāʻau antihyperglycemic waha ʻē aʻe (e like me ka metformin a i ʻole thiazolidinedione) no ka mālama ʻana i ka maʻi diabetes type 2. ʻO ka pōmaikaʻi o kēia lāʻau lapaʻau. kona mau hopena ʻaoʻao haʻahaʻa (e like me ka emi ʻana o ka hypoglycemia, ka liʻiliʻi o ke kaumaha o ke kaumaha) i ka mālama ʻana i nā waiwai glucose koko. Hoʻohana pū ʻia ʻo Exenatide (Byetta) ma kāna hopena i ka ʻōnaehana incretin.
Pahuhopu: DPP-4