JBJ-04-125-02 R-isomer

Inoa Kimia:

(R)-2-(5-fluoro-2-hydroxyphenyl)-2-(1-oxo-6-(4-(piperazin-1-yl)phenyl)isoindolin-2-yl)-N-(thiazol-2 -yl)acetamide

SMILES Code:

O=C([C@H](N(C1=O)CC2=C1C=C(C=C2)C3=CC=C(C=C3)N4CCNCC4)C5=CC(F)=CC=C5O)NC6 =NC=CS6

Code InChi:

InChI=1S/C29H26FN5O3S/c30-21-5-8-25(36)24(16-21)26(27(37)33-29-32-11-14-39-29)35-17-20- 2-1-19(15-23(20)28(35)38)18-3-6-22(7-4-18)34-12-9-31-10-13-34/h1-8, 11,14-16,26,31,36H,9-10,12-13,17H2,(H,32,33,37)/t26-/m1/s1

Ki InChi:

VHQVOTINPRYDAO-AREMUKBSSA-N

Hua'ōlelo:

Hiki ke hoʻoheheʻe: 

Waihona: 

wehewehe:

ʻO JBJ-04-125-02 kahi mea hoʻopaneʻe allosteric EGFR koho mutant me ka hana anticancer. Ma ke ʻano he ʻelele hoʻokahi, hiki iā ia ke kāohi i ka hoʻonui ʻana o ka cell a me ka EGFRL858R/T790M/C797S hōʻailona in vitro a in vivo. ʻO ka hui pū ʻana o osimertinib a me JBJ-04-125-02 ka hopena i ka piʻi ʻana o ka apoptosis, kahi pale ʻoi aku ka maikaʻi o ka ulu ʻana o ka cellular, a me ka hoʻonui ʻana i ka pono in vitro a in vivo i hoʻohālikelike ʻia me ka mea hoʻokahi wale nō.

Pahuhopu: EGFR