Flibanserin

Inoa Kimia:

1-(2-(4-(3-(trifluoromethyl)phenyl)piperazin-1-yl)ethyl)-1H-benzo[d]imidazol-2(3H)-hoʻokahi hydrochloride

SMILES Code:

O=C1NC2=CC=CC=C2N1CCN3CCN(C4=CC=CC(C(F)(F)F)=C4)CC3

Code InChi:

InChI=1S/C20H21F3N4O/c21-20(22,23)15-4-3-5-16(14-15)26-11-8-25(9-12-26)10-13-27-18- 7-2-1-6-17(18)24-19(27)28/h1-7,14H,8-13H2,(H,24,28)

Ki InChi:

PPRRDFIXUUSXRA-UHFFFAOYSA-N

Hua'ōlelo:

Flibanserin, 167933-07-5

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina).

wehewehe:

ʻO Flibanserin kahi agonist piha o ka 5-HT1A receptor (Ki = 1 nM) a, me ka haʻahaʻa haʻahaʻa, ma ke ʻano he antagonist o ka mea hoʻokipa 5-HT2A (Ki = 49 nM) a me ka antagonist a i ʻole ka nāwaliwali hapa agonist o ka D4 receptor ( Ki = 4–24 nM). ʻOiai ʻoi aku ka nui o ka pili o flibanserin no ka 5-HT1A receptor, a no nā kumu i ʻike ʻole ʻia, noho ʻo flibanserin i ka 5-HT1A a me 5-HT2A receptors in vivo me nā pākēneka like. Loaʻa i ka Flibanserin kahi haʻahaʻa haʻahaʻa no ka 5-HT2B receptor (Ki = 89.3 nM) a me ka 5-HT2C receptor (Ki = 88.3 nM), ʻo ia mau mea ʻelua e like me ka antagonist o. Hoʻohana ʻo Flibanserin i nā mea hoʻokipa 5-HT1A i ka cortex prefrontal, e hōʻike ana i ka koho ʻāina, a ua ʻike ʻia e hoʻonui i ka dopamine a me nā pae norepinephrine a hoʻemi i nā pae serotonin i ka cortex prefrontal cortex, nā hana i hoʻoholo ʻia e hoʻopili ʻia e ka hoʻāla ʻana o ka 5-HT1A. loaʻa.[12] No laila, ua wehewehe ʻia ka flibanserin ma ke ʻano he norepinephrine-dopamine disinhibitor (NDDI). Ua ʻae ʻia ʻo Flibanserin i ʻAukake 2015 no ka mālama ʻana i nā wahine pre-menopausal me ka hypoactive sexual desire disorder (HSDD).

Kuhikuhi: 5HT