GDC-0326

Inoa Kimia:

(S)-2-((2-(1-isopropyl-1H-1,2,4-triazol-5-yl)-5,6-dihydrobenzo[f]imidazo[1,2-d][1,4] ]oxazepin-9-yl)oxy)propanamide

SMILES Code:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Code InChi:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17( 20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

Ki InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Hua'ōlelo:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Hiki ke hoʻoheheʻe:Hiki ke hoʻoheheʻe ʻia ma DMSO

Waihona:0 - 4°C no ka wā pōkole (nā lā i nā pule), a i ʻole -20°C no ka wā lōʻihi (mau mahina)

wehewehe:

ʻO GDC-0326 kahi mea hoʻopaneʻe ikaika a koho i ka α-Isoform o Phosphoinositide 3-Kinase (PI3Kalpha inhibitor). Loaʻa iā GDC-0326 kahi kiʻekiʻe kiʻekiʻe o ka koho ma luna o nā kinases ʻē aʻe. Loaʻa iā GDC-0326 ka plasma CL haʻahaʻa i ke kanaka. I loko o ka ʻohana PI3 kinase, ʻehā mau papa I PI3K isoforms (α, β, δ, a me γ). ʻO kēia mau isoforms, ʻo PI3Kα ka mea maʻamau e pili pū me nā maʻi maʻi.

Pahuhopu: PI3K