BAY-850

Inoa Kimia:

N-((R)-1-(((1s,4S)-4-aminocyclohexyl)amino)-3-(4-cyanophenyl)propan-2-yl)-2-chloro-4-methoxy-5-(5 -((((R)-1-(p-tolyl)ethyl)amino)methyl)furan-2-yl)benzamide

SMILES Code:

ClC(C(C(N[C@H](CC1=CC=C(C#N)C=C1)CN[C@@H]2CC[C@H](N)CC2)=O)=C3 )=CC(OC)=C3C(O4)=CC=C4CN[C@H](C)C5=CC=C(C)C=C5

Code InChi:

InChI=1S/C38H44ClN5O3/c1-24-4-10-28(11-5-24)25(2)42-23-32-16-17-36(47-32)34-19-33(35(35 39)20-37(34)46-3)38(45)44-31(18-26-6-8-27(21-40)9-7-26)22-43-30-14-12- 29(41)13-15-30/h4-11,16-17,19-20,25,29-31,42-43H,12-15,18,22-23,41H2,1-3H3,(H ,44,45)/t25-,29-,30+,31-/m1/s1

Ki InChi:

BSISGUIVBKDTQO-QIKYYPRYSA-N

huaʻōlelo:

BAY-850; BAY850; BAY 850

Hiki ke hoʻoheheʻe:DMSO

Waihona: 

wehewehe:

"ʻO BAY-850 kahi noiʻi kemika no ka ATAD2A bromodomain e hoʻoneʻe i ka acetylated H4 peptide mai ka ATAD2 bromodomain me kahi waiwai IC50 o 20 nM (HTRF). Hōʻike nā ana MST a me BROMOscan i kahi Kd o 84.9 nM a me 120 nM, kēlā me kēia. BAY- Hōʻike ʻo 850 i ke koho maikaʻi loa ma luna o nā bromodomains ʻē aʻe (ʻaʻohe paʻi ma BROMOscan ma 10 µM) a hoʻoneʻe i ka ATAD2 lōʻihi piha mai ka chromatin i loko o nā cell ola ma kahi ʻano o 1 µM e like me ka hoʻoholo ʻana e FRAP No ka pale ʻana i nā hopena hopena ʻole o ka ≥ ʻAʻole ʻōlelo ʻia ka 5 µM (http://www.thesgc.org/chemical-probes/BAY-850) "

Manaʻo: ʻimi kemika no ka ATAD2A bromodomain