BAY598 R-isomer

Inoa Kimia:

(R,E)-N-(1-(N'-cyano-N-(3-(difluoromethoxy)phenyl)carbamimidoyl)-3-(3,4-dichlorophenyl)-4,5-dihydro-1H-pyrazol- 4-yl)-N-ethyl-2-hydroxyacetamide

SMILES Code:

CCN([C@@H]1CN(N=C1C2=CC(Cl)=C(C=C2)Cl)/C(NC3=CC=CC(OC(F)F)=C3)=N/C# N)C(CO)=O

Code InChi:

InChI=1S/C22H20Cl2F2N6O3/c1-2-31(19(34)11-33)18-10-32(30-20(18)13-6-7-16(23)17(24)8-13) 22( 28-12-27)29-14-4-3-5-15(9-14)35-21(25)26/h3-9,18,21,33H,2,10-11H2,1H3,(H ,28,29)/t18-/m1/s1

Ki InChi:

OTTJIRVZJJGFTK-GOSISDBHSA-N

huaʻōlelo:

BAY-598 R-isomer; BAY 598 R-isomer; BAY598 R-isomer

Hiki ke hoʻoheheʻe:DMSO

Waihona: 

wehewehe:

ʻO BAY-598 R-isomer ka R-isomer o BAY589. Hiki ke hoʻohana ʻia ka BAY-598 R-isomer ma ke ʻano he hui kuhikuhi. ʻO BAY-598 kahi mea hoʻopaʻapaʻa hoʻokūkū hoʻokūkū peptide no SMYD2. Loaʻa i ka BAY-598 kahi chemotype kūʻokoʻa e pili ana i ka ʻimi kemika SMYD2 o kēia manawa LLY-507. BAY-598 inhibits in vitro methylation o p53K370 me IC50 = 27 nM a ua ʻoi aku ka nui o ka 100-fold selectivity ma luna o nā histone methyltransferases a me nā pahuhopu non-epigenetic ʻē aʻe. Hoʻopili ka BAY-598 i ka methylation o p53K370 i nā pūnaewele me IC50< 1 µM. (Ma waho aʻe o kēia, loaʻa iā BAY-598 nā waiwai i kūpono me nā hoʻokolohua in vivo.) Ua kūkulu pū ʻia kahi pūhui mana, BAY-369. BAY-369 kaohi i ka in vitro methylation o p53K370 me IC50 >70 micromolar.

Pahuhopu: