PRT-060318; PRT318; P142-76
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 500mg | A Stock | 900 |
| 1g | A Stock | 1350 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
2-((1R,2S) -2-aminocyclohexyl) amino) -4- (m-tolylamino) pyrimidine-5-carboxamide
Lambar SMILES:
O=C(C1=CN=C(N[C@H]2[C@@H](N)CCCC2)N=C1NC3=CC=CC(C)=C3)N
Lambar InChi:
InChi=1S/C18H24N6O/c1-11-5-4-6-12(9-11)22-17-13(16(20)25)10-21-18(24-17)23-15-8- 3-2-7 -14(15)19/h4-6,9-10,14-15H,2-3,7-8,19H2,1H3,(H2,20,25)(H2,21,22,23,24)/ t14-,15+/m0/s1
InChi Key:
NZNTWOVDIXCHHS-LSDHHAIUSA-N
Mabuɗin kalma:
PRT-060318, PRT318, P142-76, PRT060318, PRT 060318, PRT318, PRT-318, PRT 318, 1194961-19-7
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)
Bayani:
PRT060318 shine mai hanawa mai ƙarfi da zaɓi na spleen tyrosine kinase (Syk; IC50 = 4 nM) . Yana da zaɓi, yana hana 92% na aikin Syk, yayin da sauran kinases suna riƙe> 70% aiki, a wani taro na 50 nM a cikin wani panel na 270 kinsa. PRT060318 yana hana haɓakar haɓakar ƙwayar cuta na ƙwayar plasma mai wadatar ɗan adam (IC50 = 2.5 μM) a cikin vitro kuma yana hana thrombosis a cikin ƙirar linzamin kwamfuta na transgenic na thrombocytopenia mai haifar da heparin. Yana haifar da cutar sankarar lymphocytic na yau da kullun (CLL) B cell apoptosis kuma yana hana ɓoyewar chemokines CCL3, CCL4, da CXCL13.3 PRT060318 kuma yana hana CLL B cell chemotaxis da pseudoemperipolesis.
Target: Syk
