BAY 61-3606 2HCl
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 1g | A Stock | 1200 |
| 10 g | A Stock | 5000 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
2-[7- (3,4-Dimethoxyphenyl) imidazo [1,2-c] pyrimidin-5-yl] amino] -3-pyridinecarboxamide dihydrochloride
Lambar SMILES:
O=C(N)C1=C(NC2=NC(C3=CC=C(OC)C(OC)=C3=CC4=NC=CN24)N=CC=C1.[H]Cl.[H] Cl
Lambar InChi:
InChi=1S/C20H18N6O3.2ClH/c1-28-15-6-5-12(10-16(15)29-2)14-11-17-22-8-9-26(17)20 (24-14)25-19-13(18(21)27)4-3-7-23-19;;/h3-11H,1-2H3,(H2,21,27)(H,23,24) ,25);2*1H
InChi Key:
SPMFEULFGGPQLN-UHFFFAOYSA-N
Mabuɗin kalma:
BAY 61-3606, 648903-57-5, BAY 613606, BAY-613606, BAY-61-3606
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)
Bayani:
BAY 61-3606 mai ƙarfi ne (Ki = 7.5 nM) kuma mai hanawa na Syk kinase. BAY 61-3606 ya hana ba kawai lalata ba (ƙimar IC50 tsakanin 5 da 46 nM) amma har ma matsakaicin lipid da haɗin cytokine a cikin ƙwayoyin mast. BAY 61-3606 ya kasance mai tasiri sosai a cikin basophils da aka samu daga batutuwan ɗan adam lafiya (IC50 = 10 nM) kuma yana da alama aƙalla a matsayin mai ƙarfi a cikin basophils da aka samu daga abubuwan atopic (high serum IgE) batutuwa (IC50 = 8.1 nM). BAY 61-3606 yana danne mai karɓar mai karɓa na B cell da masu karɓa don sashin Fc na siginar IgG a cikin eosinophils da monocytes.
Target: Syk
