TH-302; Evofosfamide

Sunan Sinadari:

N, N'-Bis (2-bromoethyl) phosphorodiamidic acid (1-methyl-2-nitro-1H-imidazol-5-yl) methyl ester

Lambar SMILES:

O=P(NCCBr)(NCCBr)OCC1=CN=C([N+]([O-])=O)N1C

Lambar InChi:

InChi=1S/C9H16Br2N5O4P/c1-15-8(6-12-9(15)16(17)18)7-20-21(19,13-4-2-10)14-5-3-11/ h6H,2-5,7H2,1H3,(H2,13,14,19)

InChi Key:

UGJWRPJDTDGERK-UHFFFAOYSA-N

Mabuɗin kalma:

TH-302, TH302, TH 302, Evofosfamide, 918633-87-1

Solubility:Mai narkewa a cikin DMSO

Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)

Bayani:

Evofosfamide, wanda kuma aka sani da TH-302, wani samfurin da aka kunna hypoxia wanda ya ƙunshi 2-nitroimidazole phosphoramidate conjugate tare da yuwuwar aikin antineoplastic. Halin 2-nitroimidazole na TH-302 mai kunnawa na hypoxia yana aiki a matsayin mai haifar da hypoxic, yana sakin DNA-alkylating dibromo isophosphoramide mustard moiety a cikin yankunan hypoxic na ciwace-ciwacen daji. Za a iya kiyaye kyallen jikin Normoxic saboda takamaiman aikin hypoxia na wannan wakili, mai yuwuwar rage yawan guba na tsarin. Bincika gwaje-gwajen asibiti masu aiki ko rufaffiyar gwajin asibiti ta amfani da wannan wakili. (NCI).

Manufar: Wakilin Alkylating DNA