Saukewa: AZD8186
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 100mg | A Stock | 350 |
| 500mg | A Stock | 700 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
(R) -8- (1- ((3,5-difluorophenyl)amino) ethyl) -N, N-dimethyl-2-morpholino-4-oxo-4H-chromene-6-carboxamide
Lambar SMILES:
O=C(N(C)C)C1=CC([C@@H](C)NC2=CC(F)=CC(F)=C2)=C3C(C(C=C(O3)N4CCOCC4) = O) = C1
Lambar InChi:
InChi=1S/C24H25F2N3O4/c1-14(27-18-11-16(25)10-17(26)12-18)19-8-15(24(31)28(2)3)9-20- 21 (30) 13-22 (33-23 (19)20)29-4-6-32-7-5-29/h8-14,27H,4-7H2,1-3H3/t14-/m1/s1
InChi Key:
LMJFJIDLEAWOQJ-CQSZACIVSA-N
Mabuɗin kalma:
AZD8186, AZD-8186, AZD 8186, AZD 8186, 1627494-13-6
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)
Bayani:
AZD8186 shine kuma mai hana beta isoform na phosphoinotide-3 kinase (PI3K), tare da yuwuwar aikin antineoplastic. Bayan gudanarwa, mai hanawa na PI3Kbeta AZD8186 yana zaɓan hana ayyukan PI3Kbeta a cikin hanyar siginar PI3K/Akt/mTOR, wanda zai iya haifar da raguwar haɓakar ƙwayoyin tumor. Hakanan yana haifar da mutuwar tantanin halitta a cikin PI3K-bayyana ƙwayoyin kansa. Ta musamman niyya aji I PI3K beta, wannan wakili na iya zama mafi inganci da ƙarancin guba fiye da masu hana PI3K na kwanon rufi. Alamar tsaka-tsaki ta PI3K sau da yawa ana dysregulated a cikin ƙwayoyin kansa kuma yana ba da gudummawa ga haɓakar ƙwayar ƙwayar cuta, rayuwa, da juriya na ƙari ga nau'ikan magungunan antineoplastic. A halin yanzu AZD8186 yana ƙarƙashin gwajin asibiti na Mataki na I.
Saukewa: PI3K
