Quizartinib; AC-010220; AC-220
Cikakken Bayani
Tags samfurin
| Girman Kunshin | samuwa | Farashin (USD) |
| 5g | A Stock | 1000 |
| 10 g | A Stock | 1500 |
| Ƙarin Girman Girma | Samu Magana | Samu Magana |
Sunan Sinadari:
N- (5-tert-Butylisoxazol-3-yl)-N'-{4-[7- (2-morpholin-4-ylethoxy) imidazo[2,1-b] [1,3] benzothiazol-2-yl phenyl} urea
Lambar SMILES:
O=C(NC1=CC=C(C2=CN3C(SC4=CC(OCCN5CCOCC5)=CC=C34)=N2)C=C1)NC6=NOC(C(C)(C)C)=C6
Lambar InChi:
InChi=1S/C29H32N6O4S/c1-29(2,3)25-17-26(33-39-25)32-27(36)30-20-6-4-19(5-7-20)22- 18-35-23-9-8-21 (16-24(23)40-28(35)31-22)38-15-12-34-10-13-37-14-11-34/h4-9,16-18H,10-15H2,1 -3H3, (H2,30,32,33,36)
InChi Key:
CVWXJKQAOSCOAB-UHFFFAOYSA-N
Mabuɗin kalma:
Quizartinib, AC-010220, AC010220, AC 010220, AC-220, AC220, AC 220, 950769-58-1
Solubility:Mai narkewa a cikin DMSO
Ajiya:0 - 4 ° C na gajeren lokaci (kwanaki zuwa makonni), ko -20 ° C na dogon lokaci (watanni)
Bayani:
Quizartinib shine mai hanawa na tyrosine kinase 3 da ke da alaka da FMS (FLT3; Kd = 1.6 nM) kuma yana nuna babban zaɓi don FLT3 lokacin da aka gwada shi akan wani panel na 227 ƙarin kinases. Yana hana yaduwar kwayar cutar sankarar jini ta mutum MV4-11, wanda ke dauke da maye gurbin FLT3-ITD homozygous, tare da darajar IC50 na 0.56 nM.1 A 1 mg / kg / day, an nuna quizartinib don ƙaddamar da rayuwa a cikin linzamin kwamfuta. samfurin FLT3-ITD m myeloid cutar sankarar bargo da kuma kawar da ciwace-ciwace a cikin FLT3-dogara. linzamin kwamfuta model xenograft a 10 mg/kg.
Saukewa: FLT3
