S-600918, Sivopixant

Ainm Ceimigeach:

(2S)-3-[(4E)-3-[(4-chlorophenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oxy]phenyl}imino)-1 ,3,5-triazinan-1-yl]-2-methylpropanoic acid

Còd SMILES:

O=C(O)[C@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

Còd InChi:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17) 28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

iuchair InChi:

SKZQFKBIJUXXCG-INIZCTEOSA-N

Facal-luirg:

2414285-40-6; CAS: 2414285-40-6; CAS:2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Solubility:Soluble ann an DMSO

Stòradh:Tioram, dorcha agus aig 0 - 4 C airson geàrr-ùine (làithean gu seachdainean) no -20 C airson ùine fhada (mìosan gu bliadhnaichean)

Tuairisgeul:

Tha Sivopixant, ris an canar cuideachd S-600918, na antagonist receptor P2X3 roghnach (P2X3 IC50, 4.2 nM; P2X2 / 3 IC50, 1100 nM). Sheall Sivopixant buaidh analgesic làidir anns a’ mhodal ligation nerve sciatic part-rat (modail Seltzer) de allodynia (ED50, 0.4 mg / kg).

Targaid: Antagonist receptor P2X3 roghnach