Quarfloxin

Ainm Ceimigeach:

5-fluoro-N-(2-(S)-1-methylpyrrolidin-2-yl)ethyl)-3-oxo-6-((R)-3-(pyrazin-2-yl)pyrrolidin-1-yl) )-3H-benzo[b]pyrido[3,2,1-kl]phenoxazine-2-carboxamide

Còd SMILES:

FC1=C(N2CC[C@H](C3=CN=CC=N3)C2)C(OC4=C5C=C6C(C=CC=C6)=C4)=C(N5C=C(C(NCC[ C@H]7N(C)CCC7)=O)C8=O)C8=C1

Còd InChi:

InChI=1S/C35H33FN6O3/c1-40-13-4-7-24(40)8-10-39-35(44)26-20-42 -29-15-21-5-2-3-6-22(21)16-30(29)45-34-31(42)25(33(26)43)17-27 (36)32(34)41-14-9-23(19-41)28-18-37-11-12-38-28/h2-3,5-6,11-12 ,15-18,20,23-24H,4,7-10,13-14,19H2,1H3,(H,39,44)/t23-,24+/m1/s1

iuchair InChi:

WOQIDNWTQOYDLF-RPWUZVMVSA-N

Facal-luirg:

CX 3543; CX-3543; CX 3543; Quarfloxacin

Solubility: 

Stòradh: 

Tuairisgeul:

Tha Quarfloxin, ris an canar cuideachd Quarfloxacin agus CX-3543, na derivative fluoroquinolone le gnìomhachd antineoplastic. Bidh Quarfloxin a ’cur dragh air an eadar-obrachadh eadar pròtain nucleolin agus structar DNA G-quadruplex anns an teamplaid DNA ribosomal (rDNA), eadar-obrachadh èiginneach airson biogenesis rRNA a tha ro àrd ann an ceallan aillse; briseadh air an DNA G-quadruplex seo: faodaidh eadar-obrachadh pròtain ann am biogenesis rRNA aberrant casg a chuir air synthesis ribosome agus apoptosis cealla tumhair.

Targaid: