| CAT # | Ainm toraidh | Tuairisgeul |
| CPD3611 | SB-204990 | Is e SB-204990 toradh an neach-dìon citrate-lyase làidir ATP SB-201076. Chaidh SB-204990, nuair a chaidh a thoirt seachad gu beòil do radain, a thoirt a-steach don chuairteachadh siostamach, chaidh co-chruinneachaidhean SB-201076 a bha buntainneach gu cungaidh-leigheis fhaighinn air ais anns an grùthan. Lùghdaich SB-204990 (25 mg / kg gach latha) ìrean colaistéarol plasma (suas ri 23%) agus ìrean triglyceride (suas ri 38%) anns a ’chù, le bhith a’ lughdachadh lipoprotein dùmhlachd ìosal an coimeas ri cholesterol lipoprotein àrd-dùmhlachd ìrean. Tha SB-204990 na einnsean cudromach ann a bhith a’ cumail smachd air solar substrate airson synthesis lipid de novo agus targaid enzyme a dh’ fhaodadh a bhith ann airson eadar-theachd hypolipidaemic. |
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