GDC6036; GDC6036 atropisomers

Ainm Ceimigeach:

2-Propen-1-aon, 1-[(3S)-4-[7-[6-amino-4-methyl-3-(trifluoromethyl)-2-pyridinyl]-6-chloro-8-fluoro-2- [[(2S)-1-methyl-2-pyrrolidinyl]methoxy]-4-quinazolinyl]-3-methyl-1-piperazinyl] -

Còd SMILES:

C=CC(N1C[C@H](C)N(C2=C3C=C(Cl)C(C4=NC(N)=CC(C)=C4C(F)(F)F)=C(F) )C3=NC(OC[C@H]5N(C)CCC5)=N2)CC1)=O

Còd InChi:

InChI=1S/C29H32ClF4N7O2/c1-5-21(42)40-9-10-41(16(3)13-40)27-18-12-19(30)22(26-23(29(32,) 33) 34) 15(2) 11-20 (35) 36-2 6)24(31)25(18)37-28(38-27)43-14-17-7-6-8-39(17)4/h5,11-12,16-17H,1,6- 10,13-14H2,2-4H3,(H2,35,36)/t16-,17-/m0/s1

iuchair InChi:

ZRBPIAWWRPFDPY-IRXDYDNUSA-N

Facal-luirg:

2417917-17-8 ； CAS: 2417917-17-8 ； CAS: 2417917-17-8 ； GDC6036 atropisomers; GDC-6036; GDC 6036; GDC 6036

Solubility: 

Stòradh:Tioram, dorcha agus aig 0 - 4 C airson geàrr-ùine (làithean gu seachdainean) no -20 C airson ùine fhada (mìosan gu bliadhnaichean).

Tuairisgeul:

Anns an isomer an-aghaidh cuairteachadh GDC6036 tha dà sheòrsa de isomers an-aghaidh cuairteachadh GDC6036. GDC-6036 ， Cuideachd aithnichte mar RG6330, tha e na neach-dìon KRAS G12C bith-ruigsinneach, fìor èifeachdach agus roghnach.

Targaid: KRAS G12C