Ertugliflozin
Mion-fhiosrachadh toraidh
Bathar Tags
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Ainm Ceimigeach:
(1S,2S,3S,4R,5S)-5-(4-chloro-3-(4-ethoxybenzyl)phenyl)-1-(hydroxymethyl)-6,8-dioxabicyclo[3.2.1]octane-2,3 ,4-triol
Còd SMILES:
"CCOC1=CC=C(C=C1)CC2=C(C=CC(=C2)C34C(C(C(C(O3)(CO4)CO)O)O)O)Cl"
Còd InChi:
"InChI=1S/C22H25ClO7/c1-2-28-16-6-3-13(4-7-16)9-14-10-15(5-8-17(14)23)22-20(27) )18(25)19(2 6) 21(11-24,30-22)12-29-22/h3-8,10,18-20,24-27H,2,9,11-12H2,1H3/t18-,19-,20+ ,21-,22-/m0/s1 "
iuchair InChi:
"MCIACXAZCBVDEE-CUUWFGFTSA-N"
Facal-luirg:
Ertugliflozin, PF 04971729, MK-8835,1210344-57-2
Solubility:Soluble ann an DMSO
Stòradh:0 - 4 ° C airson geàrr-ùine (làithean gu seachdainean), no -20 ° C airson ùine fhada (mìosan).
Tuairisgeul:
Tha Ertugliflozin, ris an canar cuideachd PF-04971729, na neach-dìon cumhachdach agus roghnach den cotransporter glucose 2 a tha an urra ri sodium agus tagraiche clionaigeach airson làimhseachadh tinneas an t-siùcair seòrsa 2. Sheall sgrùdadh clionaigeach gun do leasaich Ertugliflozin (1-25 mg / day) smachd glycemic, cuideam bodhaig agus cuideam fala ann an euslaintich le T2DM fo smachd suboptimally air metformin, agus chaidh gabhail ris gu math.
Targaid: SGLT-2