BMS-955176

Ainm Ceimigeach:

4-((1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-((2-(1,1-dioxidiomorpholino)ethyl)amino)-5a,5b,8,8,11a -pentamethyl-1- (prop-1-en-2-il)-2,3,3a,4,5,5a,5b,6,7,7a,8,11,11a,11b,12,13,13a ,13b-octadecahydro-1H-cyclopenta[a] chrysen-9-yl) searbhag benzoic

Còd SMILES:

O=C(O)C1=CC=C(C2=CC[C@@]3(C)[C@@](C2(C)C)([H])CC[C@@]4(C) )[C@]5(C)CC[C@](CC[C@H]6C(C)=C)(NCCN(CC7)CCS7(=O)=O)[C@@]6([H ])[C@@]5([H])CC[C@]34[H])C=C1

Còd InChi:

InChI=1S/C42H62N2O4S/c1-28(2)31-14-19-42(43-22-23-44-24-26-49(47,48)27-25-44)21-20-40( 6) 33(36(31)42)12-13-35-39(5)17-15-32(29-8-10-30(11-9-29)37(45)46)38(3, 4) 34(39)16-18-41(35,40)7/h8-11,15,31,33-36,43H,1,12-14,16-27H2,2-7H3,(H,45 ,46)/t31-,33+,34-,35+,36+,39-,40+,41+,42-/m0/s1

iuchair InChi:

XDMUFNNPLXHNKA-ZTESCHFWSA-N

Facal-luirg:

GSK3532795, GSK-3532795, GSK 3532795, BMS-955176, BMS 955176, BMS955176

Solubility: 

Stòradh: 

Tuairisgeul:

Tha GSK3532795, ris an canar cuideachd BMS-955176, na neach-dìon aibidh HIV-1 (MI) làidir, gnìomhach beòil, a chaidh air adhart tro dheuchainnean clionaigeach ìre IIb. Tha GSK3532795 a’ cothlamadh còmhdach farsaing de bhìorasan polymorphic (EC50<15 nM a dh’ ionnsaigh pannal de polymorphisms cumanta a tha a’ riochdachadh bhìoras subtype B 96.5% HIV-1) le ìomhaigh cungaidh-leigheis fàbharach ann an gnèithean preclinical.

Targaid: Neach-dìon aibidh HIV-1 (MI)