agónaí STING-4

Ainm Cheimiceach:

1,1'-(bútán-1,4-dé-il)bis(2-(1-eitil-3-meitil-1H-piorazole-5-carboxamido)-1H-beinsó[d]imidazole-5-carboxamide)

Cód Smiles:

O=C(C1=CC=C2N(CCCCN3C(NC(C4=CC(C)=NN4CC)=O)=NC5=CC(C(N)=O)=CC=C35)C(NC(C6=CC) (C)=NN6CC)=O)=NC2=C1)N

Cód InChi:

InChI=1S/C34H38N12O4/c1-5-45-27(15-19(3)41-45)31(49)39-33-37-23- 17-21(29(35)47)9-11-25(23)43(33)13-7-8-14-44-26-12-10-22(30(36)4 8)18-24(26)38-34(44)40-32(50)28-16-20(4)42-46(28)6-2/h9-12,15-18 H,5-8,13-14H2,1-4H3,(H2,35,47)(H2,36,48)(H,37,39,49)(H,38,40,50)

Eochair InChi:

ICZSAXDKFXTSGL-UHFFFAOYSA-N

Eochairfhocal:

Tuaslagthacht: 

Stóráil: 

Cur síos:

Is spreagthóir é agonist StING-4 ar agónaí receptor Interferon Genes (STING) le tairiseach coisctheach dealraitheach (IC50) de 20 nM. Is comhdhúil bunaithe ar amidobenzimidazole (ABZI) a bhaineann le dhá shiméadracht é STING agonist-4 chun ABZIs (diABZI) nasctha a chruthú le ceangal feabhsaithe le STING agus le feidhm cheallacha

Sprioc: STING