diABZI STING agonist-1
Sonraí Táirge
Clibeanna Táirge
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Ainm Cheimiceach:
(E)-1-(4-(5-carbamoyl-2-(1-eitil-3-meitil-1H-pyrazole-5-carboxamido)-7-(3-morpholinopropoxy)-1H-beinseó[d]imidazol- 1-il)but-2-ie-1-il)-2-(1-eitil-3-meitil-1H-pirazol-5-carboxamido)-7-meatocsa-1H-beansó[d]imidazole-5-carboxamide
Cód Smiles:
O=C(N)C1=CC(N=C(NC(C2=CC(C)=NN2CC)=O)N3C/C=C/CN4C(NC(C5=CC(C)=NN5CC)=O)) =NC6=C4C(OCCCN7CCOCC7)=CC(C(N)=O)=C6)=C3C(OC)=C1
Cód InChi:
InChI=1S/C42H51N13O7/c1-6-54-31(19-25(3)49-54)39(58)47-41-45-29-21-27(37(43)56)23-33( 60-5) 35(29)52(41)12-8-9-13-53-36-30(46-42(53)48-40(59)32-20-26(4)50-55( 32)7-2)22-28(38(44)57)24-34(36)62-16-10-11-51-14-17-61-18-15-51/h8-9,19- 24H,6-7,10-18H2,1-5H3,(H2,43,56)(H2,44,57)(H,45,47,58)(H,46,48,59)/b9-8 +
Eochair InChi:
JGLMVXWAHNTPRF-CMDGGOBGSA-N
Eochairfhocal:
Tuaslagthacht:
Stóráil:
Cur síos:
Is spreagthóir roghnach é diABZI StING agonist-1 ar agónaí receptor géinte interferon (STING), le EC50s de 130, 186 nM don duine agus don luch, faoi seach.
Sprioc: STING