agónaí STING-3

Ainm Cheimiceach:

(E)-1-(4-(5-carbamoyl-2-(1-eitil-3-meitil-1H-pyrazole-5-carboxamido)-1H-beinseó[d]imidazol-1-il)but-2- ga-1- yl)-2-(1-eitil-3-meitil-1H-pyrazole-5-carboxamido)-7-(3-hiodrocsaipropoxy)-1H-beinsó[d]imidazole-5-carboxamide

Cód Smiles:

O=C(N)C1=CC=C(N(C(NC(C2=CC(C))=NN2CC)=O)=N3)C/C=C/CN4C5=C(N=C4NC(C6=CC) (C)=NN6CC)=O)C=C(C(N)=O)C=C5OCCCO)C3=C1

Cód InChi:

InChI=1S/C37H42N12O6/c1-5-48-28(16-21(3)44-48)34(53)42-36-40-25-18-23(3 2(38)51)10-11-27(25)46(36)12-7-8-13-47-31-26(19-24(33(39)52)20-30(31)55- 15-9-14-50)41-37(47)43-35(54)29-17-22(4)45-49(29)6-2/h7-8,10-11,16-20, 50 H,5-6,9,12-15H2,1-4H3,(H2,38,51)(H2,39,52)(H,40,42,53)(H,41,43,54)/b8 -7+

Eochair InChi:

VHCDRDBBENBVEK-BQYQJAHWSA-N

Eochairfhocal:

Tuaslagthacht: 

Stóráil: 

Cur síos:

Is agonist StING-3, a bhaintear as paitinn WO2017175147A1 (mar shampla 10), agonist beag-mhóilín beag-mhóilín roghnach agus neamh-núicléatíde le pEC50 agus pIC50 de 7.5 agus 9.5, faoi seach. Tá éifeacht marthanach frith-meall ag STING agonist-3 agus cumas iontach chun cóireáil ailse a fheabhsú

Sprioc: STING