OTS964

Ainm Cheimiceach:

(R)-9-(4-(1-(démheitiolaimín)própán-2-il)feinil)-8-hiodrocsa-6-meitilthienó[2,3-c]quinolin-4(5H)-aon

Cód Smiles:

[H]Cl.O=C1NC2=C(C(C3=CC=C([C@H)(C)CN(C)C)C=C3)=C(O)C=C2C)C4=C1SC =C4

Cód InChi:

InChI=1S/C23H24N2O2S.ClH/c1-13-11-18(26)19(16-7-5-15(6-8-16)14(2)12-25(3)4)20-17- 9-10-28-22(17)23(27)24-21(13)20;/h5-11,14,26H,12H2,1-4H3,(H,24,27);1H/t14-; /m0./s1

Eochair InChi:

YHPWOYBWUWSJDW-UQKRIMTDSA-N

Eochairfhocal:

OTS 964, OTS-964, OTS964, 1338545-07-5

Tuaslagthacht:Intuaslagtha i DMSO

Stóráil:0 - 4°C don ghearrthéarma (laethanta go seachtainí), nó -20°C don fhadtéarma (míonna)

Cur síos:

Is inhibitor é OTS964 ar kinase próitéine de bhunadh cille T marfach atá gníomhachtaithe lymphokine (TOPK; IC50 = 28 nM). Blocann sé go sonrach cytokinesis, as a dtagann apoptosis, i raon leathan cealla ailse. Spreagann OTS964 apoptosis de chealla ailse scamhóg daonna i xenografts luiche.

Sprioc: TOPK