GDC-0326

Ainm Cheimiceach:

(S)-2-((2-(1-iseapróipil-1H-1,2,4-triazol-5-il)-5,6-dé-hidrobensó[f]imidazó[1,2-d][1,4 ]oxazepin-9-il)ocsa)própanamíd

Cód Smiles:

C[C@H](OC1=CC=C2C3=NC(C4=NC=NN4C(C)C)=CN3CCOC2=C1)C(N)=O

Cód InChi:

InChI=1S/C19H22N6O3/c1-11(2)25-19(21-10-22-25)15-9-24-6-7-27-16-8-13(28-12(3)17( 20)26)4-5-14(16)18(24)23-15/h4-5,8-12H,6-7H2,1-3H3,(H2,20,26)/t12-/m0/s1

Eochair InChi:

SIKYDKLGPWRPMZ-LBPRGKRZSA-N

Eochairfhocal:

GDC-0326, GDC0326, GDC 0326, 1282514-88-8

Tuaslagthacht:Intuaslagtha i DMSO

Stóráil:0 - 4°C don ghearrthéarma (laethanta go seachtainí), nó -20°C don fhadtéarma (míonna)

Cur síos:

Is inhibitor potent agus roghnach é GDC-0326 de α-Isoform de Phosphoinositide 3-Kinase (inhibitor PI3Kalpha). Baineann GDC-0326 amach leibhéal an-ard roghnaíochta thar kinases eile. Tá CL plasma íseal ag GDC-0326 sa duine. Laistigh den teaghlach PI3 kinase, tá ceithre isoforms PI3K rang I (α, β, δ, agus γ). As na isfhoirmeacha seo, is é PI3Kα an ceann is coitianta a bhaineann le hailse.

Sprioc: PI3K