TTN21277

Ainm Cheimiceach:

(2S, 4R)-1-((S)-2-(3-(2-((5-((4-(3-clóra-4-fluarafheinile)aimín)-7-meatocsaquinazolin-6-il)) ocsaí)pentyl)ocsa)ethocsa)própanamido)-3,3-démheitiolbútanail)-4-hiodrocsa-N-(4-(4-meitilthiazol-5-il)beinsile)pirrolidine-2-carbosaicimíd

Cód Smiles:

O=C([C@H]1N(C([C@@H](NC(CCOCCOCCCCCOC2=CC3=C(NC4=CC=C(F)C(Cl)=C4)N=CN=C3C=C2OC) )=O)C(C)(C)C)=O)C[C@H](O)C1)NCC5=CC=C(C6=C(C)N=CS6)C=C5

Cód InChi:

InChI=1S/C47H57ClFN7O8S/c1-29-42(65-28-53-29)31-11-9-30(10-12-31)25-50-45(59)38-22-33(57) 26-56(38)46(60)43(47(2,3)4)55-41(58)15-18-63-20-19-62-16-7-6-8-17-64- 40-23-34-37(24-39(40)61-5)51-27-52-44(34)54-32-13-14-36(49)35(48)21-32/h9- 14,21,23-24,27-28,33,38,43,57H,6-8,15-20,22,25-26H2,1-5H3,(H,50,59)(H,55, 58)(H,51,52,54)/t33-,38+,43-/m1/s1

Eochair InChi:

NICKHWYZMNLEPJ-TZSMONEZSA-N

Eochairfhocal:

PROTAC 3 bunaithe ar Gefitinib; NTN21277; NTN-21277; TTN 21277

Tuaslagthacht: 

Stóráil: 

Cur síos:

Is PROTAC VHL-earcaithe é NTN21277, ar a dtugtar PROTAC 3 Gefitinib-bhunaithe freisin a spreagann díghrádú mutants EGFR agus EGFR le DC50 de 11.7 nM agus 22.3 nM do chill HCC827 (Exon 19 del) agus H3858R (L).

Sprioc: EGFR