S-600918, Sivopixant

Gemyske namme:

(2S)-3-[(4E)-3-[(4-chloorfenyl)methyl]-2,6-dioxo-4-({4-[(pyridin-2-yl)oksy]fenyl}imino)-1 ,3,5-triazinan-1-yl]-2-methylpropanoic acid

SMILES Koade:

O=C(O)[C@@H](C)CN1C(N(CC2=CC=C(Cl)C=C2)/C(NC1=O)=N/C3=CC=C(OC4=NC =CC=C4)C=C3)=O

InChi Koade:

InChI=1S/C25H22ClN5O5/c1-16(22(32)33)14-31-24(34)29-23(30(25(31)35)15-17-5-7-18(26)8- 6-17)28-1 9-9-11-20(12-10-19)36-21-4-2-3-13-27-21/h2-13,16H,14-15H2,1H3,(H,32,33)( H,28,29,34)/t16-/m0/s1

InChi Key:

SKZQFKBIJUCXCG-INIZCTEOSA-N

Keyword:

2414285-40-6; CAS:2414285-40-6; CAS：2414285-40-6; Sivopixant; S-600918; S 600918; S600918

Oplosberens:Oplosber yn DMSO

Opslach:Droog, tsjuster en by 0 - 4 C foar koarte termyn (dagen oant wiken) of -20 C foar lange termyn (moannen oant jierren)

Beskriuwing:

Sivopixant, ek bekend as S-600918, is in selektive P2X3 receptor antagonist (P2X3 IC50, 4.2 nM; P2X2/3 IC50, 1100 nM). Sivopixant toande in sterke analgetyske effekt yn it rat partiel sciatic nerve ligation model (Seltzer model) fan allodynia (ED50, 0.4 mg / kg).

Doel: Selektive P2X3 receptor antagonist