ቢኤምኤስ-955176

የኬሚካል ስም

4-(1R,3aS,5aR,5bR,7aR,11aS,11bR,13aR,13bR)-3a-(2- (2- (1,1-dioxidothiomorpholino)ethyl)አሚኖ)-5a,5b,8,8,11a -ፔንታሜቲል-1-(ፕሮፕ-1-ኤን-2-yl)-2፣3፣3a፣4፣5፣5a፣5b፣6,7,7a,8,11,11a,11b,12,13,13a ,13b-octadecahydro-1H-cyclopenta[a] chrysen-9-yl) ቤንዚክ አሲድ

የፈገግታ ኮድ፡-

O=C(O)C1=CC=C(C2=CC[C@@]3(C)[C@@](C2(C)C)([H])CC[C@@]4(C) )[C@]5(ሲ)CC[C@](CC[C@H]6C(C)=C)(NCCN(CC7)CCS7(=ኦ)=ኦ)[C@@]6([H) ])[C@@]5([H])CC[C@]34[H])C=C1

የኢንቺ ኮድ

InChi=1S/C42H62N2O4S/c1-28(2)31-14-19-42(43-22-23-44-24-26-49(47,48)27-25-44)21-20-40( 6)33(36(31)42)12-13-35-39(5)17-15-32(29-8-10-30(11-9-29)37(45)46)38(3) 4)34(39)16-18-41(35,40)7/h8-11,15,31,33-36,43H,1,12-14,16-27H2,2-7H3,(H,45) ,46)/t31-,33+,34-,35+,36+,39-,40+,41+,42-/m0/s1

የኢንቺ ቁልፍ፡

XDMUFNNPLXHNKA-ZTESCHFWSA-N

ቁልፍ ቃል፡

GSK3532795፣ GSK-3532795፣ GSK 3532795፣ BMS-955176፣ BMS 955176፣ BMS955176

መሟሟት; 

ማከማቻ፡ 

መግለጫ፡-

GSK3532795፣እንዲሁም BMS-955176 በመባል የሚታወቀው፣በደረጃ IIb ክሊኒካዊ ሙከራዎች ያለፈ ኃይለኛ፣በቃል ንቁ፣ሁለተኛ-ትውልድ ኤችአይቪ-1 ብስለትን የሚያግድ (MI) ነው። GSK3532795 የ polymorphic ቫይረሶችን ሰፊ ሽፋን ያጣምራል (EC50<15 nM ወደ 96.5% የኤችአይቪ-1 ንዑስ ዓይነት ቢ ቫይረስ ተወካይ ወደ ፓነል የጋራ ፖሊሞርፊዝም) በቅድመ ክሊኒካል ዝርያዎች ውስጥ ተስማሚ የፋርማሲኬቲክ ፕሮፋይል ያለው።

ዒላማ፡ ኤችአይቪ-1 ብስለትን የሚገታ (MI)