I-Zidesamtinib; I-NVL-520

Igama Lekhemikhali:

(6R)-22-ethyl-54-fluoro-42,6-dimethyl-22H,42 H-7-oxa1(3,5)-pyridina-2(3,4)-pyrazola-4(4,5)- [1,2,3]triazola5(1,2)-benzenacycloheptaphan-16-amine

Ikhodi ye-SMILES:

FC1=CC([C@](OC2=C(N=CC3=C2)N)(C)[H])=C(C=C1)C4=NN(N=C4CC5=C3N(N=C5)CC )C

Ikhodi ye-InChi:

I-InChI=1S/C22H22FN7O/c1-4-30-21-13(11-26-30)7-18-20(28-29(3)27-18)16-6-5-15(23)9- 17(16)12(2)31-19-8-14(21)10-25-22(19)24/h5-6,8-12H,4,7H2,1-3H3,(H2,24,25 )/t12-/m1/s1

I-InChi Key:

DTWUUAFTYSMNQX-GFCCVEGCSA-N

Igama elingukhiye:

2739829-00-4;CAS:2739829-00-4;CAS:2739829-00-4;Zidesamtinib; I-NVL-520; I-NVL520; I-NVL 520

Ukunyibilika: 

Isitoreji:Eyomile, emnyama futhi ku-0 - 4 C isikhathi esifushane (izinsuku ukuya emavikini) noma -20 C isikhathi eside (izinyanga kuya eminyakeni).

Incazelo:

I-Zidesamtinib (i-NVL-520) iyisivimbeli esisebenzayo, esikhethayo, esisebenza ngomlomo, nesivimbelayo segazi nobuchopho esivumela ukuthi kuhlanganiswe i-ROS1 kanye ne-resistance mutation inhibitor.

Ithagethi: I-ROS1