I-SB-204990

Igama Lekhemikhali:

trans-5-[6-(2,4-Dichlorophenyl)hexyl]tetrahydro-3-hydroxy-2-oxo-3-furanacetic acid

Ikhodi ye-SMILES:

O=C(O)C[C@@]1(O)C(O[C@H](CCCCCCC2=CC=C(Cl)C=C2Cl)C1)=O

Ikhodi ye-InChi:

I-InChI=1S/C18H22Cl2O5/c19-13-8-7-12(15(20)9-13)5-3-1-2-4-6-14-10-18(24,11-16(21) 22)17(23)25-14/h7-9,14,24H,1-6,10-11H2,(H,21,22)/t14-,18-/m1/s1

I-InChi Key:

YTRNLFYTHYWDAU-RDTXWAMCSA-N

Igama elingukhiye:

SB-204990, SB 204990, SB204990

Ukunyibilika: 

Isitoreji: 

Incazelo:

I-SB-204990 iyi-prodrug ye-ATP citrate-lyase inhibitor enamandla i-SB-201076. I-SB-204990, lapho ilawulwa ngomlomo kumagundane, yafakwa ekujikelezeni kwesistimu, ukugxila okuhlobene ne-pharmacologically kwe-SB-201076 kwatholwa esibindi. I-SB-204990 (25 mg/kg ngosuku) iphinde yehlisa amazinga e-cholesterol e-plasma (kufika ku-23%) kanye namazinga e-triglyceride (kufika ku-38%) enjeni, okukhethekile ehlisa i-low-density lipoprotein uma kuqhathaniswa ne-high-density lipoprotein cholesterol. amazinga. I-SB-204990 iyi-enzyme ebalulekile ekulawuleni ukunikezwa kwe-substrate ye-lipid synthesis de novo kanye nethagethi ye-enzyme engaba khona yokungenelela kwe-hypolipidemic.

Ithagethi: