I-ATP citrate-lyase

IKATI #	Igama Lomkhiqizo	Incazelo
I-CPD3611	I-SB-204990	I-SB-204990 iyi-prodrug ye-ATP citrate-lyase inhibitor enamandla i-SB-201076. I-SB-204990, lapho ilawulwa ngomlomo kumagundane, yafakwa ekujikelezeni kwesistimu, ukugxila okuhlobene ne-pharmacologically kwe-SB-201076 kwatholwa esibindi. I-SB-204990 (25 mg/kg ngosuku) iphinde yehlisa amazinga e-cholesterol e-plasma (kufika ku-23%) kanye namazinga e-triglyceride (kufika ku-38%) enjeni, okukhethekile ehlisa i-low-density lipoprotein uma kuqhathaniswa ne-high-density lipoprotein cholesterol. amazinga. I-SB-204990 iyi-enzyme ebalulekile ekulawuleni ukunikezwa kwe-substrate ye-lipid synthesis de novo kanye nethagethi ye-enzyme engaba khona yokungenelela kwe-hypolipidemic.